Frontline: Neuropilin-1: a surface marker of regulatory T cells
نویسندگان
چکیده
منابع مشابه
Neuropilin 1 guides regulatory T cells into VEGF-producing melanoma
Regulatory T cells (Tregs) interfere with antitumor immune responses, hence facilitating oncogenesis and tumor progression. Our recent findings indicate that neuropilin 1, which is highly expressed by Tregs, mediates the infiltration of these cells into the tumor in a vascular endothelial growth factor (VEGF)-dependent manner, thereby contributing to cancer-associated immunosuppression.
متن کاملNeuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
Foxp3(+) CD4(+) T helper cells called regulatory T (T reg) cells play a key role in controlling reactivity to self-antigens and onset of autoimmunity. T reg cells either arise in thymus and are called natural T reg (nT reg) cells or are generated in the periphery through induction of Foxp3 and are called inducible T reg (iT reg) cells. The relative contributions of iT reg cells and nT reg cells...
متن کاملConcomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice
Regulatory T (Treg) cells are characterized by the expression of CD4, CD25 and the intracellular Foxp3. However, these markers do not indicate whether Treg cells are thymic derived Treg (tTreg) cells or peripherally induced Treg (pTreg) cells. Recently, Helios and Neuropilin-1 (Nrp1) has been reported as potential markers for tTreg cells. Herein, we used flow cytometry to examine the proportion...
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The interaction of T cells with dendritic cells (DCs) determines whether an immune response is launched or not. Recognition of antigen leads to formation of immunological synapses at the interface between the cells. The length of interaction is likely to determine the functional outcome, because it limits the number of MHC class II-peptide complexes that can be recruited into the synapse. Here,...
متن کاملExpression of neuropilin-1 on in vivo induced regulatory T cells
One of the current questions surrounding CD4 T regulatory cells (Tregs) is the role of natural and induced Tregs in tumor tolerance. Natural Tregs are CD4 T cells that leave the thymus expressing FoxP3 and displaying regulatory potential. Induced Tregs leave the thymus as a naïve CD4 T cell (FoxP3-), but are skewed by conditions encountered during antigen recognition to express FoxP3 and gain r...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2004
ISSN: 0014-2980
DOI: 10.1002/eji.200324799